COMPANY PROFILE
At TLC we specialize in the custom synthesis of complex organic compounds for use as reference standards by the bio-medical and pharmaceutical industries around the world.
UNCOMPROMISED QUALITY
At TLC, quality is not just a commitment, it is ingrained in our culture. Our extensive COA, which includes HPLC, NMR, MS, IR, EA, GC, Water Content, residual solvents and Assay, coupled with ISO 17034 and ISO 17025 accreditations, serves as a testament to our unwavering dedication to delivering products that meet the highest standards of excellence in the industry.
EXTENSIVE INVENTORY
TLC currently offers over 22,000 certified reference standards from stock and we add approximately 2,000 new standards yearly. Our product line includes Active Pharmaceutical Ingredients (API), drug impurities and metabolite standards, as well as their stable isotope labelled analogues and amino acid/peptide drug standards.
New Stable Isotope-Labeled Reference Standard: Tacrolimus-13C-d2
We are pleased to announce the successful development of Tacrolimus-13C-d2, a high-quality stable isotope-labeled (SIL) reference standard designed to support demanding analytical and bioanalytical applications.
Tacrolimus is a potent immunosuppressive agent used in both systemic and topical therapies, with significant analytical and bioanalytical relevance due to its narrow therapeutic index and complex pharmacokinetics. Accurate and reliable quantification is essential across a range of studies, including clinical, pharmacokinetic, and bioanalytical investigations. This 13C-d2 labeled analog is intended to support LC-MS/MS method development, validation, and quantitative analysis related to tacrolimus.
This material has been produced to a high standard of quality, with high isotopic enrichment and excellent chemical purity as detailed on the certificate of analysis (COA). The 13C-d2 labeling option provides a reliable internal standard for tacrolimus analysis, helping to minimize isotopic overlap and analytical interference. This supports accurate, precise, and reproducible quantitation in complex biological matrices and is well suited for GLP-compliant studies, helping reduce the risk of regulatory questions related to assay performance.
Given the structural complexity of tacrolimus and the challenges associated with incorporating stable isotopes while maintaining high analytical quality, this compound can be difficult to source at a consistently high quality level. Please contact us for availability and a quotation.
New Stable Isotope-Labeled Reference Standard: Tacrolimus-13C-d2
We are pleased to announce the successful development of Tacrolimus-13C-d2, a high-quality stable isotope-labeled (SIL) reference standard designed to support demanding analytical and bioanalytical applications.
Tacrolimus is a potent immunosuppressive agent used in both systemic and topical therapies, with significant analytical and bioanalytical relevance due to its narrow therapeutic index and complex pharmacokinetics. Accurate and reliable quantification is essential across a range of studies, including clinical, pharmacokinetic, and bioanalytical investigations. This 13C-d2 labeled analog is intended to support LC-MS/MS method development, validation, and quantitative analysis related to tacrolimus.
This material has been produced to a high standard of quality, with high isotopic enrichment and excellent chemical purity as detailed on the certificate of analysis (COA). The 13C-d2 labeling option provides a reliable internal standard for tacrolimus analysis, helping to minimize isotopic overlap and analytical interference. This supports accurate, precise, and reproducible quantitation in complex biological matrices and is well suited for GLP-compliant studies, helping reduce the risk of regulatory questions related to assay performance.
Given the structural complexity of tacrolimus and the challenges associated with incorporating stable isotopes while maintaining high analytical quality, this compound can be difficult to source at a consistently high quality level. Please contact us for availability and a quotation.