Your trusted source for Reference Standards, manufactured and certified in-house

While our previously developed Tacrolimus-13C-d2 standard was successfully used in a range of analytical applications, several clients working with this large and structurally complex molecule indicated that a greater mass difference was preferred for highly sensitive LC-MS/MS methods. In response, our laboratory rapidly adapted to this market need and developed Tacrolimus-13C-d4—demonstrating our flexibility and commitment to delivering reference standards aligned with evolving customer requirements.

Tacrolimus-13C-d4 has been produced with high isotopic enrichment and excellent chemical purity as detailed in its COA, making it well suited for analytical applications including:

• LC-MS/MS quantitative analysis
• Bioanalytical method development and validation
• Pharmacokinetic and therapeutic drug monitoring studies
• GLP-compliant analytical workflows

The development of a highly enriched multi-labeled tacrolimus standard presents significant synthetic and analytical challenges, and materials of this type can be difficult to source at consistently high quality.

Please contact TLC for availability and quotation.

From June 16-18, visit us at booth E2G26 to learn more about our latest developments, discuss industry trends, and explore new collaboration opportunities in the pharmaceutical and healthcare sectors.

Our team looks forward to connecting with partners and professionals from across the globe and sharing how TLC continues to support innovation and growth in the industry.

See you in Shanghai!

Tretinoin (all-trans retinoic acid), CAS No. 302-79-4 is widely used in pharmaceutical, dermatological, and analytical research. This d6-labeled analog is designed to support LC-MS/MS method development, validation, and quantitative analysis where a robust internal standard is critical.

Previously available Tretinoin-d5 materials have demonstrated lower isotopic enrichment and residual unlabeled content, which can create potential interference challenges for end users. To overcome this, TLC developed a superior d6-labeled version by directly introducing six deuterium atoms onto two methyl groups using deuterated reagents, resulting in stronger label stability and improved analytical performance.

Our final product achieves:

• 99.5% deuterium enrichment
• No detectable d0 content
• Stable deuterium incorporation resistant to label loss during testing
• Improved suitability as an internal standard for sensitive LC-MS/MS applications
• COA available here: COA

The development of Tretinoin-d6 required a highly complex synthetic route involving more than 15 steps. Both intermediates and the final product are highly unstable and sensitive to light and temperature, requiring strict oxygen-free, light-free, and low-temperature conditions throughout reaction, workup, and purification processes.

Due to the technical difficulty of synthesis and the exceptional isotopic quality achieved, Tretinoin-d6 represents a significant advancement for laboratories requiring dependable SIL reference standards.

Please contact TLC for availability and quotation.